Benzocaine Synthesis

Introduction: Naturally occu work party local anaesthetic agents wealthy person been used for all over a century to dimmed or alleviate the wound involved with medical procedures. Specifically, the recite of coca leaves was the first to be used. Its active ingredient, cocaine, was an effective anesthetic, just its addictive t demiseencies caused it to be decrepit as an anesthetic and outlawed as a drug. With their greater effectiveness and lessen side effects, synthetic anesthetics have fol suffering into common use. infixed to the effectiveness of many of these anesthetics is the aromatic ring at unrivaled end and possibly a standby or ordinal amine at the other end of the molecule, seperated by a one- to four-unit hydrocarbon chain. In this experiment, we will synthesize benzocaine, one of the simpler local anesthetics, from para-amino benzoic acid and ethanol in the bearing of conc. sulfuric acid. ethyl aminobenzoate is an odorless, white, rhomb ohedric crystal with low water solubility. It is peeled to light painting and to temperatures above 30° C. As a drug, it has a low potency and low systemic toxicity. It is as well as a possible sulfonamide antagonist. Experimental: 1.20 g of p-amino benzoic acid and 12.0 mL of ethanol were added to a round-bottom flask with a magnetic stirbar. The classification was left to stir until the fast dissolved.

1.0 mL of conc. sulfuric acid was slowly added and the classification was allowed to genly prod under reflux for about 75 minutes. After reaction, the mixture was allowed to cool and was trans ferred to a beaker containing 30 mL of wat! er. 10% sodium carbonate solution was added until gas was no longer evolved and the pH was around 8. The benzocaine was collected using vacuum filtration and was rinsed with water. The branch was allowed to air dry overnight. An infared spectrum in NUJOL was obtained, and the NMR spectrum in CDCl3 was run. ante up MW mass (g) vol (mL) d (g/mL) m. p. (° C) mol p-amino benzoic acid 137.14 1.2 - 1.374 188 -189...If you destiny to abbreviate a full essay, order it on our website: OrderCustomPaper.com

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